Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls
Identifieur interne : 000461 ( Main/Exploration ); précédent : 000460; suivant : 000462Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls
Auteurs : Greetje Vande Velde [Belgique] ; Uwe Himmelreich [Belgique] ; Michal Neeman [Israël]Source :
- Contrast Media & Molecular Imaging [ 1555-4309 ] ; 2013-11.
Abstract
The central dogma of molecular biology, namely the process by which information encoded in the DNA serves as the template for transcriptional activation of specific mRNA resulting in temporal and spatial control of the translation of specific proteins, stands at the basis of normal and pathological cellular processes. Serving as the primary mechanism linking genotype to phenotype, it is clearly of significant interest for in vivo imaging. While classically, imaging revolutionized the ability to phenotype the anatomical and physiological impact of induction of changes in gene expression, the preceding molecular events remained invisible. Reporter gene‐based imaging techniques provide a window for in vivo visualization of such transcriptional activation events. In addition to the widespread use of fluorescent and bioluminescent reporter genes and development of a number of reporter genes for positron emission tomography (PET) imaging, there has been significant progress in the development of reporter genes for MRI. With the development of strategies for cellular based therapies, such imaging tools could become central components for personalized patient monitoring. © 2013 The Authors. Contrast Media & Molecular Imaging published by John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/cmmi.1590
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001623
- to stream Istex, to step Curation: 001576
- to stream Istex, to step Checkpoint: 000117
- to stream Main, to step Merge: 000461
- to stream Main, to step Curation: 000461
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls</title><author><name sortKey="Velde, Greetje Vande" sort="Velde, Greetje Vande" uniqKey="Velde G" first="Greetje Vande" last="Velde">Greetje Vande Velde</name></author><author><name sortKey="Himmelreich, Uwe" sort="Himmelreich, Uwe" uniqKey="Himmelreich U" first="Uwe" last="Himmelreich">Uwe Himmelreich</name></author><author><name sortKey="Neeman, Michal" sort="Neeman, Michal" uniqKey="Neeman M" first="Michal" last="Neeman">Michal Neeman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:18ACF821FD25FE8F2D2F231130DF9A61DDE1831E</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/cmmi.1590</idno><idno type="url">https://api.istex.fr/document/18ACF821FD25FE8F2D2F231130DF9A61DDE1831E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001623</idno><idno type="wicri:Area/Istex/Curation">001576</idno><idno type="wicri:Area/Istex/Checkpoint">000117</idno><idno type="wicri:doubleKey">1555-4309:2013:Velde G:reporter:gene:approaches</idno><idno type="wicri:Area/Main/Merge">000461</idno><idno type="wicri:Area/Main/Curation">000461</idno><idno type="wicri:Area/Main/Exploration">000461</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls</title><author><name sortKey="Velde, Greetje Vande" sort="Velde, Greetje Vande" uniqKey="Velde G" first="Greetje Vande" last="Velde">Greetje Vande Velde</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Biomedical MRI, KU Leuven, O&N I Herestraat 49 ‐ box 505, 3000, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Himmelreich, Uwe" sort="Himmelreich, Uwe" uniqKey="Himmelreich U" first="Uwe" last="Himmelreich">Uwe Himmelreich</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Biomedical MRI, KU Leuven, O&N I Herestraat 49 ‐ box 505, 3000, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Neeman, Michal" sort="Neeman, Michal" uniqKey="Neeman M" first="Michal" last="Neeman">Michal Neeman</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Biological Regulation, Weizmann Institute of Science, 76100, Rehovot</wicri:regionArea><wicri:noRegion>Rehovot</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Contrast Media & Molecular Imaging</title><title level="j" type="abbrev">Contrast Media Mol. Imaging</title><idno type="ISSN">1555-4309</idno><idno type="eISSN">1555-4317</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-11">2013-11</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="424">424</biblScope><biblScope unit="page" to="431">431</biblScope></imprint><idno type="ISSN">1555-4309</idno></series><idno type="istex">18ACF821FD25FE8F2D2F231130DF9A61DDE1831E</idno><idno type="DOI">10.1002/cmmi.1590</idno><idno type="ArticleID">CMMI1590</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1555-4309</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The central dogma of molecular biology, namely the process by which information encoded in the DNA serves as the template for transcriptional activation of specific mRNA resulting in temporal and spatial control of the translation of specific proteins, stands at the basis of normal and pathological cellular processes. Serving as the primary mechanism linking genotype to phenotype, it is clearly of significant interest for in vivo imaging. While classically, imaging revolutionized the ability to phenotype the anatomical and physiological impact of induction of changes in gene expression, the preceding molecular events remained invisible. Reporter gene‐based imaging techniques provide a window for in vivo visualization of such transcriptional activation events. In addition to the widespread use of fluorescent and bioluminescent reporter genes and development of a number of reporter genes for positron emission tomography (PET) imaging, there has been significant progress in the development of reporter genes for MRI. With the development of strategies for cellular based therapies, such imaging tools could become central components for personalized patient monitoring. © 2013 The Authors. Contrast Media & Molecular Imaging published by John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Israël</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Velde, Greetje Vande" sort="Velde, Greetje Vande" uniqKey="Velde G" first="Greetje Vande" last="Velde">Greetje Vande Velde</name></noRegion><name sortKey="Himmelreich, Uwe" sort="Himmelreich, Uwe" uniqKey="Himmelreich U" first="Uwe" last="Himmelreich">Uwe Himmelreich</name></country><country name="Israël"><noRegion><name sortKey="Neeman, Michal" sort="Neeman, Michal" uniqKey="Neeman M" first="Michal" last="Neeman">Michal Neeman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000461 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000461 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:18ACF821FD25FE8F2D2F231130DF9A61DDE1831E
|texte= Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls
}}
| This area was generated with Dilib version V0.6.25. |  |